Supplementary Figure 2 Explanation of sensitivity analysis with observation time truncated at the time of the event. Observed IRRs of drug monotherapy for the main analysis in SCCS and sensitivity analysis. A key assumption of the SCCS is that the exposure distribution within the observation period and the observation period itself must be independent of prior event times. This could have been violated for some subjects, because use of an nsNSAID without gastroprotection is relatively contraindicated after UGIB. By truncating follow-up at the time of UGIB, we observed that the IRRs changed in magnitude for some drugs. We used a change of 10% of the initial estimate as an arbitrary cutoff to quantify the magnitude of the change.
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